Pharmacokinetics and pharmacodynamics of Astragali Radix-Corni Fructus Herb-pair Extract, in kidney-yin deficiency model

To investigate the pharmacokinetics and pharmacodynamics of Astragali Radix-Corni Fructus herb-pair in kidney-yin deficiency model, which was made by continuously oral gavage thyroxine. A simple rapid LC-MS/MS method developed validated for determination loganin morroniside rat plasma used study. The significantly changed AUC(0-∞), Cmax CLz/F morroniside. T1/2z increased rats. For study, liver index, kidney ALT, TBIL, UREA, CREA level mice were examined. had been proved to be effective treatment affecting liver, kidney, UREA CREA, showed positively correlated with dose. studies pathological status could offer more valuable information future application herb-pair.